Caspofungin induces programmed cell death in Saccharomyces cerevisiae
نویسندگان
چکیده
منابع مشابه
Pheromone Induces Programmed Cell Death in S. cerevisiae
Programmed cell death is a ubiquitous process in multicellular organisms. The pathways by which cells in multicellular organisms trigger cell death have been extensively characterized. A typical scenario for programmed cell death development includes activation of the MAP kinase cascade, accumulation of reactive oxygen species, release of cytochrome c from mitochondria into cytoplasm as a conse...
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Caspofungin was the first member of a new class of antifungals called echinocandins to be approved by a drug regulatory authority. Like the other echinocandins, caspofungin blocks the synthesis of β(1,3)-D-glucan of the fungal cell wall by inhibiting the enzyme, β(1,3)-D-glucan synthase. Loss of β(1,3)-D-glucan leads to osmotic instability and cell death. However, the precise mechanism of cell ...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2010
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.24.1_supplement.485.2